This article selects the relevant data of 16 cities in Anhui Province from 2011 to 2020 as the research sample, calculates the coupling and co scheduling of their ecological civilization construction and regional economy, and uses the local Moran index to draw Lisa clustering maps for the two time nodes of 2015 and 2020 to further explore their spatial characteristics. The research results show that, on the whole, the average coupling coordination degree of Anhui Province fluctuated around 0.51 from 2011 to 2020, with a certain degree of stability; Comparing 16 cities in the province, it is found that there is still a large gap between prefecture‐level cities. The average coupling coordination degree of Hefei in the past decade is the first in Anhui Province, while the average coupling coordination degree of Fuyang and Huainan in the past decade is juxtaposed at the tail of Anhui Province. The average coupling coordination degree of Hefei is 1.971 times that of Fuyang and Huainan; From a spatial perspective, in 2015 and 2020, the changes in urban agglomeration areas were not significant, and the overall coordination level was not high. Among them, Chizhou City and its surrounding cities had a relatively high degree of coordination within the province, enabling them to communicate with surrounding cities. The above research provides a certain reference for the country to formulate policies to promote the construction of ecological civilization and coordinated economic development in various regions.