Promoting the close integration of innovation and entrepreneurship education and professional education is the intrinsic need of higher vocational colleges to further promote innovation and entrepreneurship education, is the inevitable choice of higher vocational colleges to deepen the development of professional education, and is also the objective requirement of cultivating innovative talents needed by the society. However, the development of innovation and entrepreneurship education and professional education is almost independent of each other. This seriously restricts the sustainable development of innovation and entrepreneurship education.[1]This paper starts from expounding the progress of the integration of innovation and entrepreneurship education and professional education in higher vocational colleges, analyzes the main problems, and further puts forward relevant strategies.