Under the new background of "new engineering disciplines construction plan", the cultivation of innovative engineering talents has become the source power to promote the development of new economy, optimize the human capital structure and drive the close combination of production and education. With the acceleration of the new round of scientific and technological revolution and industrial transformation, the reconstruction of innovation and entrepreneurship education mode matching the cultivation of new engineering disciplines talents has become an important guarantee to improve the quality of higher engineering education. This paper systematically analyzes the key factors affecting the innovation and entrepreneurship education mode of local colleges and universities under the background of "new engineering disciplines disciplines", explores the realization path of innovation and entrepreneurship education to meet the needs of stakeholders of "new engineering disciplines construction plan", and puts forward safeguard measures and policy Suggestions.