In order to fundamentally analyze and solve the new problems and challenges faced by the development of Vocational Education under the new situation, the supply side structural reform of vocational education from the perspective of Marx's supply and demand theory is imperative. Guided by Marx's theory of supply and demand, this paper analyzes and studies the imbalance of supply and demand of Vocational Education in China. In order to further analyze the essence and reasons of the imbalance of supply and demand of vocational education, this paper applies the supply side reform theory to the reform of vocational education. The results provide theoretical and practical basis for the supply side structure reform of Vocational Education in China. This is not only the need of the supply side structure reform of China's vocational education, but also the need of China's economic and social development, and the only way to form higher vocational education with Chinese characteristics.