Manufacturing as the pillar industry of the national economy, now facing great challenges brought by multiple pressure, at the same time, the global value chain also in the new round of scientific and technological revolution and industrial transformation presents a digital transformation trend, the continuous development of digital technology has gradually become a favorable starting point for realizing high‐quality economic development.In this context, this paper first analyzes the development status and existing problems of the manufacturing industry in the Yangtze River Delta, and then puts forward four paths for the application of digital technology "layout innovation chain, upgrade industrial chain, optimize supply chain and enhance value chain" from the four segments of "research and development, production, circulation and service". Finally, based on the model and combined with the problems mentioned above, this paper puts forward some suggestions to promote the high‐quality development of manufacturing industry in the Yangtze River Delta.