College counselors play an important role in the "three comprehensive education" system, play an important role and shoulder the important responsibility of cultivating people by virtue. Counselors play an important role in talent training in private colleges and universities under the perspective of "three comprehensive education". Under the new educational situation, the work of counselors in private colleges and universities faces many problems and challenges. This paper analyzes the challenges in the work of counselors in private universities from the perspective of "three comprehensive education", and studies the new methods and new paths of the work of counselors.