Quantitative Modeling of Oil-in-Water Microemulsion for Assay and Therapy in Aerospace Medicine

The miniaturization of biological and chemical processes is generally believed to be useful in designing airspace medicine recently. Like a lab-on-a-chip, a microchip performing multiphase material synthesis operations with integrated transducers leads to a wide use of microfluidics, creating the controllability of investigation in mass transport process that becomes more and more crucial along with increasing demand for microfluidic designs with low pressure drop. This study presents a quantitative analysis of an oil-in-water (O/W) microemulsion flow in a microfluidic T-junction for improving its formation mechanism. The experiment is based on an adjustment of flow rates that forms O/W microemulsions with different constituent ratios, resulting in changes of flow patterns. In response to the pressure drops, demonstrated periodic fluctuations are consistently shown and deeply related to the regularity of microemulsion dynamics. The response surface methodology (RSM) introduced in the modeling of microemulsion formations demonstrates well predicted results with measurement. Accordingly, the microemulsion quality and quantity can be precisely controlled by inspecting the flow properties.

關鍵字

Microemulsion ； Microfluidic ； Resonance ； Pressure drop ； Response surface methodology

並列摘要

微型生醫元件適用於航太醫學檢測與治療，故藉由整合多種感測裝置於單一晶片，發展微流體量化技術已是研究趨勢。在高度侷限環境中，微流體可控機制及其靈敏度對於醫療效率提升尤其重要。鑒此，本研究旨在發展可精確操控微流體之量化模型，提供合理可行之水油混合微型乳液操作依據，進以藉由設計參數改善其成型機理。經分析，流量造成乳液不同成分比，導致流譜與壓降改變，且其成型品質與流場規律性密切相關，證明模型可用性。

並列關鍵字

微型乳液；共振；壓降；響應曲面法

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