During past 20 years, world-wide economics was changed dramatically. Enterprises faced the challenge how to globalize, digitize and fasten the processes. How to fully utilize the world-wide expertise and advantage is key topic in Global Logistics Management operation. The study explores Air Cargo industry and compares a global air express company and a local forwarder company in door-to-door service area. The study based on Value Nets to analyze the business strategy and how to apply in IT strategy. For a local forwarder to expand international air cargo door-to-door service, the study provides practical suggestion in business strategy and IT Strategy. The local forwarder could improve customer satisfaction and provide better competitive advantage.