- 學位論文
運動員之輔酶Q10濃度與胰島素阻抗、抗氧化力及活動量之相關性探討
The relationship between coenzyme Q10 status and insulin resistance, antioxidative capacity, and physical activity in athletes
摘要
運動員因長期高強度訓練而產生較多自由基，造成身體承受較高之氧化損傷。輔酶Q10是一個良好的抗氧化劑，參與抵抗高氧環境下的抗氧化作用，故本研究目的為了解運動員之輔酶Q10濃度與胰島素阻抗、抗氧化力及活動量之相關性。本研究為觀察性研究，受試者分別為接受專業訓練之運動員（n＝43）及非常規運動訓練之一般健康大專生（n＝25）。研究期間利用問卷收集受試者健康相關資料、活動量及三天飲食紀錄，並測量體位、血液生化值、發炎指標、血糖評估相關指標、抗氧化力及輔酶Q10濃度。結果發現，運動員之白血球輔酶Q10濃度顯著低於健康組（p＜0.01）；總抗氧化力顯著高於健康組（p＜0.01）。運動員之輔酶Q10濃度與空腹血糖、糖化血色素、胰島素及HOMA-IR呈顯著負相關，與QUICKI呈顯著正相關（p＜0.05）。此外，運動員輔酶Q10濃度與抗氧化酵素活性（過氧化氫酶及麩胱甘肽過氧化酶）、血清總抗氧化能力、維生素A及維生素E濃度呈顯著正相關性（p＜0.05）。在活動量方面，運動員輔酶Q10濃度顯著與活動量（休閒活動當量及行走活動當量）有關（p＜0.05）。由上述結果推論：運動員有較低之白血球輔酶Q10濃度及胰島素阻抗，並有較高之總抗氧化能力，且輔酶Q10濃度與胰島素阻抗呈顯著負相關；與抗氧化力呈顯著正相關。因此，提升運動員體內之輔酶Q10營養狀況對其提高抗氧化能力及增加胰島素之敏感性應有益。
並列摘要
Athletes may suffer from a higher level of oxidative stress due to long-term high-intensity training. Coenzyme Q10 is a good antioxidant that can scavenge free radicals to prevent cells from oxidative damage. The purpose of this study was to investigate the relationship between coenzyme Q10 status and insulin resistance, antioxidative capacity, and physical activity in athletes. This study was designed as an observational study. We recruited 43 well-training athletes and 25 healthy subjects for the control group. During the study, we collected subjects’ medical-related health history, physical activity questionnaire (IPAQ), and 3-day dietary records from the questionnaires. The values of anthropometry, hematological data, inflammation, glycemic parameters, antioxidative capacity, and coenzyme Q10 were measured in the study. The results show that athletes had a significantly lower level of white blood cell (WBC) coenzyme Q10 (p < 0.01); and a higher level of Trolox equivalent antioxidant capacity (TEAC, p < 0.01) than healthy subjects. In addition, coenzyme Q10 status was negatively correlated with fasting glucose, HbA1c, insulin, and HOMA-IR; and positively correlated with QUICKI (p < 0.05) in athletes. With regard to antioxidant capacity, coenzyme Q10 status was positively correlated with antioxidant enzymes activity (catalase and glutathione peroxidase), serum TEAC, vitamin A, and vitamin E (p < 0.05). Regarding physical activity, coenzyme Q10 status was significantly correlated with MET-minutes/week at leisure-time and walking in athletes (p < 0.05). In conclusion, athletes showed lower levels of WBC coenzyme Q10 and insulin resistance; and a higher level of TEAC than healthy subjects. Coenzyme Q10 status was significantly negative associated with insulin resistance and positive associated with antioxidant capacity. Thus, evaluated coenzyme Q10 status in athletes might enhance their antioxidant capacity and insulin sensitivity.
參考文獻
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