口腔微生物與全身性疾病關聯性之文獻回顧

Literature Reviews of the Association Between Oral Microbes and Systemic Diseases

陳信宇(HSIN-YU CHEN)

指導教授 ： 徐慶琳

中山醫學大學/健康管理學院/國際健康產業經營管理碩士在職專班/碩士(2022年)

https://doi.org/10.6834/csmu202200193

摘要

人類口腔環境中具有相當多的微生物種類。包含細菌、古細菌、真菌、原生動物和病毒。每一項種類都具有特定的表徵與作用性。這些的物種在口腔內會相互作用成一個平衡的系統。近期有許多研究顯示口腔內的致病菌與全身性的疾病似乎有相當的關聯性。例如: 阿茲海默症、齲齒、牙周病、心臟疾病、心血管疾病、妊娠併發症、糖尿病與癌症等等相關疾病。因此，本研究將收集有關口腔微生物引起的相關疾病之文獻，探討並分析口腔致病菌與全身性疾病的相關性。從過去的文獻指出，口腔疾病確實與上述的全身性疾病致病因子有關。經常是因為口腔環境中微生物的生態被破壞造成人類致病。研究結果表明，口腔疾病將會提高阿茲海默症 Alzheimer's Disease、齲齒Dental caries、牙周病Periodontal Disease、心臟疾病Heart Disease、心血管疾病Cardiovascular disease、妊娠並發症Pregnancy complications、糖尿病Diabetes與口腔癌Oral Cancer等全身性疾病的患病機率。因此，對於口腔保健與預防是目前相當重要的議題。不論是學校教育或是衛生政策都需要確實落實，提升人類對口腔保健的維護的意識，進而減少疾病之發生。基於上述結果，本研究顯示口腔致病菌將影響口腔環境，會破壞平衡造成人體疾病的發生。維護良好的口腔保健與清潔將有助於疾病的發生。

關鍵字

口腔保健 ； 全身性疾病 ； 口腔微生物 ； 口腔致病菌 ； 癌症

並列摘要

The human oral environment contains a considerable number of microbial species. Contains bacteria, archaea, fungi, protozoa and viruses. Each species has specific characteristics and functions. These multiple species interact within the mouth to develop a balanced system. A number of recent studies have shown that oral pathogens appear to be associated with systemic disease. For example: Alzheimer's disease, dental caries, periodontal disease, heart disease, cardiovascular disease, pregnancy complications, diabetes and cancer and other related diseases.Therefore, this study will collect related diseases caused by oral microorganisms. To explore and analyze the correlation between oral pathogenic bacteria and systemic diseases. The results of the study show that oral diseases are indeed related to the above-mentioned systemic disease causative factors from the past literature. Human disease is often caused by the destruction of the ecology of microorganisms in the oral environment. The results of the study suggest that oral disease will increase the risk of systemic diseases such as Alzheimer's Disease, Dental caries, Periodontal Disease, Heart Disease, Cardiovascular disease, Pregnancy complications, Diabetes and Oral Cancer. Therefore, oral health and prevention is a very important topic at present. Whether it is school education or health policy, it needs to be implemented to increase human awareness of oral health maintenance and reduce the occurrence of diseases. Based on the above results, this study shows that oral pathogenic bacteria will affect the oral environment, disrupt the balance and cause the occurrence of human diseases. Maintaining good oral health and cleanliness will help the disease develop.

並列關鍵字

Oral Health ； Systemic Diseases ； Oral Microbes ； Oral Pathogens ； Cancer

參考文獻

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