具阻抗量測之高壓可調PRF周邊神經電刺激器

本論文使用脈衝式射頻電刺激參數(PRF)來刺激周邊神經。其脈衝式射頻電刺激參數目前已在臨床上用來阻斷背根神經節，治療下背痛與降低交感神經作用來減緩顏面神經痛。市面上傳統中低週波的經皮神經電刺激器會因為表皮阻抗高，而無法讓能量直接深入神經。除了貼片之外亦可透過電針，達到比電針灸更好更持久的效果，此研究將使用臨床上PRF所使用的電刺激參數，藉此做為電針以及貼片來刺激周邊神經以達到減緩慢性疼痛的效果。此次設計的PRF電刺激器主要分三個部分，1.Boost升壓控制電路。2.阻抗與電流量測。3.MCU控制與計算數據並驅動顯示介面。刺激時有兩個通道一為具整流的PRF參數與未整流的PRF參數。PRF振幅透過Boost電路控制，並透過OPA與小電阻組成的電流量測電路達到電流控制與阻抗量測的目的，最後透過MCU運算將數值顯示在LCD上。最後我們與中興院區的醫生合作進行人體試驗，透過人體試驗來驗證我們提出的方式對於慢性疼痛的治療是否可行。

關鍵字

阻抗；止痛；電刺激；射頻脈衝；電療；周邊神經；生醫電子

並列摘要

The purpose of the study is to stimulate the peripheral nerves using Pulsed Radio frequency (PRF). PRF has been used to block the dorsal root ganglia (DRG) and sympathetic role in clinical. The traditional low-frequency transcutaneous electrical nerve stimulation cannot effectively stimulate nerve because of epidermal impedance is too high. In addition to electrodes, electro-acupuncture (EA) use the PRF can be better and more lasting results. This study uses Pulsed Radio frequency (PRF) in the clinical, stimulates surrounding nerves and reaches the goal of easing chronic pain by Electrodes and EA for stimulate the peripheral nerves of treatment. This PRF peripheral nerve stimulation is mainly divided into three parts; one for the BOOST converter decides PRF Amplitude, another for the impedance measurement, and the other for MCU control and calculates data. There are two channels in PRF while stimulating, one for the Rectified PRF, the other for the Tradition PRF. BOOST converter decides PRF amplitude, and achieves the purpose of current control and impedance measurement by the current measurement circuit consisted of OPA and resistance. Finally, data value will be displayed on LCD through MCU computation. Last, we cooperate with doctors of Taipei City Hospital to conduct human trials, validation our method on treatment for chronic pain by these human trials.

並列關鍵字

Impedance ； Pain relief ； Stimulation ； Stimulator ； PRF ； Peripheral nerve ； Biomedical engineering

參考文獻

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具阻抗量測之高壓可調PRF周邊神經電刺激器

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