水溶性幾丁聚醣之物理分析與流變探討

The Study on physical analyze and Rheological of water-soluble Chitosan Solutions

林文雁(Wen-Yan Lin)

指導教授 ： 芮祥鵬

國立臺北科技大學/工程學院/有機高分子研究所/博士(2012年)

摘要

幾丁質(chitin)為天然聚合物，具有良好特色的物理特性，生物降解，生物相容性，無毒性。而幾丁聚醣(chitison)是幾丁質去乙醯化(Deacetylated)，在生醫材料方面為重要的應用高分子，但不溶於水只溶於酸，如甲酸、醋酸及乳酸等，使得幾丁聚醣的發展有所限制。
因此本篇論文藉由Glycidyltrimethylammonium Chloride改值幾丁聚醣。並將不溶於水的幾丁聚醣和改質後的GTMAC系殼聚醣利用微管是震盪流變儀(V-E System)來量測此動態黏彈性質。利用Maxwell模型敘述幾丁聚醣（CS）水溶液。由儲存模數(G’)和損耗模數(G”)的交叉點隨CS的濃度增加往低頻率的區域移動。提出了Maxwell進行模擬。令人關注的是，G’和G”的交叉點不會隨著GTMAC水溶液的濃度而改變，進一步求出重疊濃度C *；最後將GTMAC的幾丁聚醣藉由高分子濃度、離子強度和溫度等因素來研究流變行為，由實驗數據進而了解其物理性質。

關鍵字

幾丁聚醣 ； 流變學 ； 重疊濃度 ； 黏彈性質

並列摘要

Chitosan with well-characterized biological properties natural polymer，The biodegradation, biocompatibility, and nontoxic. Chitosan (chitison) Chitin deacetylation (Deacetylated),an important application of polymer biomaterials , butinsoluble in water only soluble in acid , such as formic acid , acetic acid and lactic acid，thus making the development of chitosan to be limited.
. In this study, chitosan was synthesized with Glycidyltrimethylammonium Chloride The dynamic viscoelastic property of water-soluble GTMAC chitosan and water-insoluble chitosan were measured by oscillation rheometer (VE System) .
A simple Maxwell Model accurately describes a regular chitosan (CS) solution. The G’, G” crossover shifted toward lower frequencies as the CS concentration increased. A modified Maxwell Model. Interestingly, the crossover of G’ and G” was found to be independent of the GTMAC chitosan concentration,Further calculated the overlap concentration, C*. Finally,Studies have also reported that the rheological behavior of GTMAC chitosan depends on the polymer concentration、 ionic strength and the temperature, to understand their physical properties from experimental data concentration.

並列關鍵字

Chitosan ； Rheology ； Overlap concentration ； viscoelastic properties

參考文獻

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