- 學位論文
利用具有生物組織感測之PRF止痛晶片
An implantable PRF stimulator with inductive coupling impedance sensing for pain relief
摘要
近年來，生醫晶片正是各個產業關注的新興產業，而在本論文中將提出一種新式架構針對一長期植入的電刺激器的電極與欲受治療之部位所產生的增生組織的治療情況來做分析。 在本篇論文中也與台大醫學與工程研究所一起共同研究『植入式射頻脈衝電刺激無線系統晶片於疼痛控制之應用』針對脊椎的L4與L5部位治療下背痛，並且利用PRF刺激波形(Pulse Radio Frequency)的特性2Hz的週期，且有25ms的刺激時間的短脈衝訊號來阻斷神經與大腦之間的傳導路徑。 而在一個植入裝置，經長期置入體內經常會發現有組織增生問題造成電極端與刺激部位的阻抗增加造成治療未達到預期理想；而為了避免此情況發生，則提出一種利用兩線圈的近場耦合技巧感應出組織內阻抗增生問題，並且將其阻抗增生情況回傳至醫師端，則可由醫師判斷要將輸入的能量提高與否，再經由無線能量的耦合至體內進而提高欲受刺激部位的電壓訊號。
並列摘要
Recent years, every industrial are concern about the biomedical chips. Then in this will be proposed a new method for implant stimulator in long term curing and measuring tissue hyperplasia with increase impedance problem. In this paper also cooperate with Institute Biomedical Engineering NTU NSC project. For curing low back pain in spine L4 and L5, then stimulated L4 and L5 nerves by PRF (Pulse Radio Frequency) 2Hz and 25ms short pulse in spine nerve blocking pain signal path to brain. A implant device within long term implant in human body that also find this kind of problem tissue hyperplasia it will increase impedance between electron and tissue. For the stimulating treatment will not achieve desired result in the ideal. To avoid this problem happened, this paper proposed a new method by using two coil then sensing the implant tissue impedance. It can feedback impedance information for doctor. Then making a correct decision in curing stimulates pulse voltage increase or not. By using wireless power deliver into the implant device. The power can be controlled outside with more safety concerns.