以台灣癌症登記為例建構相容於caBIG™技術之台灣區網格點

The TCR Cancer Registry – a case study of caCORE based data standards implementation to integrate with the Cancer Biomedical Informatics Grid

陳新博(Shin-Bo Chen)

指導教授 ： 徐建業

臺北醫學大學/醫學科技學院/醫學資訊研究所/碩士(2011年)

摘要

caBIG是一個資訊網路工具；其允許研究組織及個體能輕易地分享、整合及分析資料。caBIG已經開發了一個全共通互用性的IT網絡系統，能輔助加乘整體癌症研究領域。台灣癌症登記起始於1979年，為行政院衛生署國民健康局所規畫並資助，50床以上的醫院強制申報新發癌症個案記載於癌症登記資料庫。台灣癌症登記由癌症登記顧問團隊協助，涵蓋16個不同領域之專家成員。台灣癌症登記主要目標為調查台灣癌症發生率。美國NCICB已建立一個caCORE核心技術；我們期望建立一個語法及語意共通互用的生醫資訊統並使其相容於caCORE架構。caCORE架構包含三個主要原件： (1) Enterprise Vocabulary Services (EVS)；(2) cancer Data Standards Repository (caDSR)；(3) caCORE SDK 及相關模型驅動系統的工具。由於現今並無台灣癌症登記之電子資料標準，發展一個相容於caBIG國際標準格式對台灣癌症研究領域是非常需要的。在本研究中，我們提供了一個以台灣癌症登記族群資料庫的案例實作，以caCORE基礎技術來實現之。透過此建構過程，我們期望建立一個台灣區網格點；以六大步驟：(1) 建立「台灣癌症登記資訊模型」；(2) 語意化註記動作；(3) 轉化資訊模型為中繼資料；(4) 格網系統核心元碼生成；(5) 系統相容性覆核；(6) 完成部屬caBIGTM系統網格點。藉由語意模型方法學，台灣癌症登記可成為癌症研究的電子資料標準。現今，我們以caCORE技術為基礎建立了癌症資料標準的原型，包含癌症資訊格網系統及台灣區網格點，而標準化通用資料元也完成釋出並公開查詢；未來我們將持續發展癌症相關資料元及應用至臨床醫學或轉譯領域。

關鍵字

癌症登記 ； 格網系統 ； caBIG ； caCORE ； 通用資料元 ； caDSR ； 共通互用性

並列摘要

Background: caBIG is a network of information and tools. It allows institutions and individuals to easily share, integrate, and analyze data. A “fully interoperable” IT network has been developing by caBIG that will supercharge the entire field of cancer research. The Taiwan Cancer Registry (TCR) is organized and funded by the Health Department of the central government. The TCR was established in 1979. Hospitals with a capacity of more than 50-bed capacity are recruited to participate in reporting all newly diagnosed malignant neoplasms to the registry. The TCR is assisted by a Cancer Registry Advisory Board, comprising 16 expert members from various fields. The TCR's primary goal is to survey the incidence of cancer in Taiwan. The NCICB has created a core infrastructure called caCORE. We developed a syntactically and semantically interoperable biomedical information system, which confirmed the caCORE framework. The framework has three key components: (1) Enterprise Vocabulary Services (EVS), (2) cancer Data Standards Repository (caDSR), (3) caCORE SDK and associated tools for model-driven software engineering of systems. Because currently there is no electronic data standard for TCR, developing a nationwide standard format and confirming to caBIG is essential to cancer research society in Taiwan.Methods: In this study, we provide a case study of caCORE based data standard implementation of the TCR, which is a population-based database. By following the building process for caCORE-based services, we expect to create our TCR node on the Grid in six steps: (1) creating UML model of TCR, (2) semantic annotation, (3) transforming UML model into metadata, (4) SDK Code Generation, (5) Compatibility Reviewing, (6) creating a Node on the Grid.
Result: A prototype of caCORE-based TCR data standard has been established, including the grid TCR information system and caGrid node. Also, we develop caDSR data elements which are released and available in CDE browser for reusing. The TCR cancer registry is a basis of electronic data standards in cancer research using caBIG semantic modeling methodology. Furthermore, we will extend our data elements to clinical medicine and translation research.

並列關鍵字

cancer registry ； caBIG ； caCORE ； common data elements ； caDSR ； interoperability

參考文獻

47. Facility Oncology Registry Data Standards (FORDS): Revised for 2007. Chicago, American College of Surgeons; 2006.

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2. Langella, S., et al., Sharing data and analytical resources securely in a biomedical research Grid environment. J Am Med Inform Assoc, 2008. 15(3): p. 363-73.

3. Oster, S., et al., caGrid 1.0: a Grid enterprise architecture for cancer research. AMIA Annu Symp Proc, 2007: p. 573-7.

4. Oster, S., et al., caGrid 1.0: an enterprise Grid infrastructure for biomedical research. J Am Med Inform Assoc, 2008. 15(2): p. 138-49.