非結晶氧化鈦薄膜之表面特性及生物相容性研究

Research of Surface properties and biocompatibility on amorphous titanium oxide film

顏西成(YEN,HSI-CHEN)

指導教授 ： 林家正

臺北醫學大學/口腔醫學院/醫療器材產業碩士專班/碩士(2014年)

摘要

本研究涉在鈦金屬的表面進行微弧氧化（MAO）修飾，其表面
呈現具有良好潤濕性的粗糙多孔氧化膜，經微弧氧化處理過的表面顯
示銳鈦礦和金紅石二氧化鈦晶體以及非晶相結構。再者，添加鈣和磷
誘導微弧放電，透過觀察MG63 成骨樣細胞和血小板在金屬表面的貼
附性進行評估，結果顯示經微弧氧化處理後的鈦金屬表面具有比控制
組的鈦金屬具有相當良好的血液和生物相容性。

關鍵字

微弧氧化 ； 濕潤性 ； 生物相容性 ； 血液相容性

並列摘要

This study involved modification of the surface of Ti by micro-arc
oxidation (MAO). A rough and porous oxide film with good wettability
was formed on the Ti surface. This MAO-treated film exhibited a
meta-amorphous structure comprising crystalline anatase and rutile TiO2
as well as amorphous phases. In addition, the incorporation of Ca and P
in the MAO-treated film was induced by micro-arc discharge. The
biological responses of the MAO-treated surfaces were evaluated by
observing the adhesion of MG63 osteoblast-like cells and platelets. The
MAO-treated Ti had a considerably better biocompatibility and blood
compatibility than untreated Ti.

並列關鍵字

micro-arc oxidation ； wettability ； biocompatibility ； blood compatibility

參考文獻

[1.] V. Salih and J.C. Knowles, “Hydroxyapatite and Titania Sol-Gel

Composite Coatings on Titanium for Hard Tissue Implants,”

Mechanical and In Vitro Biological Performance. J. Biomed. Mater.

Res. Part B: Appl. Biomater., 72B [1] 1-8 (2005).

[2.] H. GU LERYU Z and H. Cimenoglu, “Effect of thermal oxidation on