The competition of printed circuit board industry is getting more and more violent. Facing the high investment and dynamic market environment, making an effective and helpful decision for keeping long term core competition is a key for enterprise development. In this research, we will apply simulation optimization technology to find out the optimal solution of product mix, which under capacity limit, outsourcing decision, and risk factors as dynamic demand and defective rate. This optimal solution can support the process of decision making, as find out the niche market and determine expand factory issue. Then, we will apply distributed computation technology to improve the performance of simulation optimization.