介孔生醫玻璃製劑應用於牙本質小管封填研究

Mesoporous Bioactive Glass Acting as a Desensitizing Agent in Dentinal Tubule Occlusion

蕭宇成(Yu-Cheng Hsiao)

指導教授 ： 石啟仁

高雄醫學大學/藥學院/香粧品學系碩士班/碩士(2012年)

摘要

就現今的研究來說，利用填塞牙本質小管而降低刺激性被認為是治療牙本質敏感有效的方式之一。由於介孔生醫玻璃具有良好的生物相容性與骨誘導性的特點，使其在治療牙本質敏感應用上極具潛力。本研究以溶膠-凝膠法製備介孔生醫玻璃 (Mesoporous bioactive glass, MBG) 與不同計量比磷酸 (phosphoric acid, PA) 混合成製劑後，均勻塗抹於牙本質試片表面，藉由 X 光繞射分析儀 (XRD)、掃描式電子顯微鏡 (SEM)、以及傅立葉轉換紅外線光譜儀 (FTIR) 分別觀察粉體的晶相、表面型貌、牙本質小管的封填效果以及鍵結。結果顯示；製劑主要晶相為磷酸二氫鈣 (Ca(H2PO4)2•H2O)，與 30% 及 40% 磷酸溶液混合 10 分鐘的介孔生醫玻璃製劑可滲透進入牙本質小管的深度大於 80 ?慆，從本研究結果得知介孔生醫玻璃與磷酸混合後對於封填牙本質小管具有良好效果，且其作用時間短、操作性佳，應用於臨床抗牙本質過敏症具有良好的潛力。

關鍵字

介孔生醫玻璃 ； 磷酸 ； 牙本質過敏症

並列摘要

In recent studies, sealing of exposed dentinal tubules is generally considered as one of effective strategy to treat dentin hypersensitivity. Mesoporous bioactive glass (MBG) is a potential material for treating dentin hypersensitivity due to its excellent biocompatibility and osteoconductivity. In this study, MBG powder preparation by sol-gel method mixed with different calculate ratio of phosphoric acid (PA) was applied on the dentin specimen. We used X-Ray Diffractometer (XRD), Scanning electronic microscope (SEM), and Fourier Transform Infrared (FTIR) to investigate the crystallite phase and surface topography of MBG agents, the occlusion ability of dentinal tubules, and the interatomic bonding. The results showed that the major crystallite phase of MBG agents was monocalcium phosphate monohydrate (Ca(H2PO4)2•H2O). MBG paste, mixed from 30% and 40% PA, had the ability to create the penetrate depth greater than 80 µm. These results showed that MBG paste mixed with phosphoric acid solution have a great ability for occluding dentinal tubules; it has short reaction time and good operability, and these agents have potential for the treatment of dentin hypersensitivity.

並列關鍵字

Mesoporous bioactive glass ； phosphoric acid ； dentin hypersensitivity

參考文獻

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