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  • 學位論文

2-(6-取代-3(Z)-己烯-1,5-雙炔)苯胺之醯胺衍生物之合成與生物活性探討

Synthesis and Biological Activities of Amide Derivatives of 2-(6-Aryl-3(Z)hexen-1,5-diynyl)anilines

指導教授 : 吳明忠

摘要


化合物24, 30, 40和41在所有合成的新型烯雙炔化合物中對人類多種癌細胞具有較佳細胞抑制活性,其平均 GI50 值在 0.19 10-6M?搤 31.2 10-6M之間。化合物 24, 30, 40和41 利用流式細胞儀對於K-562(血癌細胞)此種細胞株作細胞週期時,皆有相當高的比例滯留在G2/M phase。其中化合物 40 之程式性凋亡 (31.57 %) 較控制組 (7.5 %) 在濃度50 10-6M時高出 4 倍為最佳。

並列摘要


Compounds 24, 30, 40 and 41 displayed good growth inhibition activity against various human cancer cell lines and the average GI50 values of these compounds are from 0.19 10-6M to 31.2 10-6M. These compounds also arrested K-562 cells in the G2/M phase and induced apoptosis . Comparing to the apoptosis area (31.57%) caused by compound 40 , it showed almost four times higher than control (7.5%) in 50 10-6M.

並列關鍵字

enediyne antitubulin agent

參考文獻


柒、參 考 文 獻
1. Hung, D. T.; Jamison, T. F.; Schreiber, S. L. Chem. Biol. 1996, 3, 623.-639.
2. Jordan, M. A.; Wilson, L. Curr. Opin. Cell Biol. 1990, 10, 123-130.
3. Vitale, I.; Antoccia, A.; Cenciarelli, C.; Crateri, P.; Meschini, S.; Arancia, G.; Pisano, C.; Tanzzarella, C. Apoptosis. 2006, 12, 155-166.
4. Schiff, P. B.; Fant, J.; Horwitz, S. B. Nature 1979, 277, 665-667.

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