治療神經系統疾病之藥物的開發研究: 具不同碳鏈長度的多樣性神經醯胺之神經節苷酯Hp-s1類似物的合成

Study on the Development Used of the Drugs in Treating the Neurological Disorders: The Synthesis of the Neuritogenic Ganglioside Hp-s1’s Analogues with Various Phytoceramide Moiety Containing Different Carbon Chain Lengths

彭佳淇(Chia-Chi Peng)

指導教授 ： 蔡祐輔

中原大學/理學院/化學研究所/碩士(2019年)

https://doi.org/10.6840/cycu201900808

摘要

本論文旨在合成Hp-s1的類似物 NGLH-1並測試其生物活性。
在此，以D-lyxose為起始物，建構出植物鞘胺醇衍生物;
以D-glucose為起始物，建構出葡萄醣衍生物; 以N-Acetyl neuraminic acid為起始物，建構出唾液酸衍生物，之後將與實驗室同仁提供的化合物進行化學選擇性(chemoselective)醣苷化反應(glycosylation)及[1+1+2]的合成策略，目前已合成出主架構NGLH-1 (18-16)。

關鍵字

神經節苷脂

並列摘要

In this thesis, we purposed to synthesize neuritogenic ganglioside Hp-s1’s Analogues NGLH-1.
In plan , we used D-lyxose to construct phytosphingosine;
D-glucose to construct acceptor; N-Acetyl neuraminic acid to construct
promoter, then use chemoselective glycosylation and [1+1+2] strategy. Now we have constructed our main structure NGLH-1(18-16)
with the compound laboratory provided.

並列關鍵字

Ganglioside

參考文獻

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