下肢周邊動脈阻塞多通道偵測系統

Multi-Channel Detecting System For Lower Limbs Peripheral Arterial Occlusion

呂威承(Wei-Cheng Lu)

指導教授 ： 蔡正倫

中原大學/工學院/生物醫學工程研究所/碩士(2018年)

https://doi.org/10.6840/cycu201800792

摘要

患有周邊動脈血管阻塞疾病的老年人口正逐年增加，動脈阻塞尤其好發於下肢動脈。由於動脈血管阻塞會直接影響肌肉的帶氧濃度，透過量測肌肉運動時的肌氧濃度變化便可以推估血管的阻塞程度。此研究研製了一套可以同時量測多個位置之肌肉氧濃度變化的系統，由肌肉狀況來判斷不同供血動脈的阻塞。
此系統利用光源與光檢測器之間的長距離來確保穿透偵測到皮下深層的肌肉組織，並使用不同波長的近紅外光源來檢測出不同血紅素的成分比例並推算出組織帶氧量的變化。透過不同的驗證實驗，確認了只要量測時將探頭確實黏貼固定，就可得到很好的量測重現性與可信度。量測到受測者在踮腳運動前後的肌氧濃度變化也符合生理上應有的反應，其中運動時肌氧濃度的回復時間參數具有最高的重現性。未來將繼續透過臨床的研究實驗，累積判斷血管阻塞發生的統計參數，並在早期篩選出周邊動脈的阻塞，以提早進行復健與治療。

關鍵字

周邊動脈阻塞 ； 近紅外光譜 ； 踮腳運動 ； 氧飽合濃度

並列摘要

The patients of peripheral arterial occlusion disease has been increasing with demographic aging in recent years. Peripheral arterial occlusion has high risk to occur in the lower extremity. The occlusion of arteries can cause low oxygen saturation level in the muscle, especially after exercise. This could be used as an index of arterial occlusion. In this study, a multi-channel oxygen saturation measurement system for muscle was developed for assessing the occlusion of lower arteries.
The long distance between light sources and photo detector ensures the deep muscle tissue under skin is measured. The oxygenation of tissue is calculated from the ratio of hemoglobin derivatives measured by multi near infrared wavelengths. Through verification experiments, the repeatability and reliability of measurement can be achieved if the sensing probes are firmly fixed. The change in oxygen saturation of muscle during and after tip-toe exercise matches the physiological responses reported in literature. The time constant of recovery has the best repeatability, and more clinical studies will be carried out to acquire the criteria for evaluating occlusion in arteries.

並列關鍵字

peripheral arterial occlusion ； near-infrared spectroscopy ； tip-toe exercise ； oxygen saturation

參考文獻

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