本研究以代謝症候群為主要檢測病症,此病症以脂締素蛋白質在人體中的正常濃度為作為判病的依據,因此探討以磁性標籤免疫分係法的優勢進行蛋白質檢測。嘗試以自行設計的感測器做磁性的量測,並使用WINSON WSH201感測器直接量測磁流體,以銜接檢測磁性標籤免疫分析法的目的。 本論文主要專注於磁流體、磁珠和磁性感測器的分析和研究,並設計與下線感測陣列晶片,提供磁性檢測的需求,其內容包含了溫度補償電路、電壓控制電流源、霍爾感測器、折疊疊接放大器等電路。從電路設計、電路佈局、佈局後模擬、感測器設計和晶片量測將會在本論文中說明。 本研究完成的部分包含使用TSMCD35製程和UMCU18MEMS製程完成感測器以及驅動電路的設計,整合了電感線圈入晶片內,使晶片更符合檢測磁珠的環境。
In the study, the protein calls adiponectin, is the main detecting protien. The concentration of adiponectin, in human blood, can cause metabolic syndrome. Using the magnetic beads to labeling the protein can be an advantage method for protein detecting system. In order to detect the magnetic field of magnetic bead, design the hall sensor base on CMOS MEMS process or CMOS BioMEMS process, and use WINSON WSH201 hall IC. This thesis focuses on analysis magnetic fluid, magnetic bead and magnetic sensor, also design and tap-out the sensor array chip. The chip contains bandgap reference circuit, voltage control current source circuit, hall sensor, folded cascode amplifier circuit etc. In the following chapters will discuss from sensor and circuit design, circuit layout to chip measurement. In this thesis had completed two chips base on TSMC 0.35um process and UMC 0.18um MEMS process. The Chips also integrated inductors to fit the measurement of Bio-system for biomedical application.