磁性感測陣列及生物檢測系統電路設計

本論文開發一應用於薛格連氏症候群檢測的磁性感測系統，此病狀以血液或唾液內的抗原抗體濃度作為罹患疾病的判別，而檢測方式將採用磁性標籤免疫分析法取代原本的酵素免疫分析法進行量測。另外，本論文探討磁性奈米粒子的特性，並自行設計感測器與前端讀出電路，進行磁性的檢測。本研究之重點有兩部分:一為設計磁性感測器並驗證其特性，二為開發一磁性感測器與讀出電路之複合式晶片。本文將採用半導體製程相容的陣列式霍爾感測器以增加感測器的靈敏度。磁性訊號透過霍爾感測陣列轉換為電訊號，由開關電路進行選擇所需霍爾單元，接著送至讀出電路進行後續的訊號處理。讀出電路包含帶差能隙參考電路、振盪器、截波儀表放大器等電路。從電路設計到電路佈局與模擬均於本論文中說明。本論文完成透過台灣積體電路製造公司TSMC 0.18μm CMOS 1P6M製程實現感測器測試晶片與磁性感測器與讀出電路之複合式晶片，亦整合磁化線圈於晶片內，最後規劃未來整體量測系統使晶片更符合量測磁珠之環境。

關鍵字

薛格連氏症候群、磁性奈米粒子、霍爾感測器、霍爾陣列、帶隙能參考電路、電流式截波儀表放大器、低通濾波器

並列摘要

This thesis is focused on the development of a magnetic sensing system to detect Sjögren's Syndrome. This is a chronic autoimmune disease where the body's white blood cells destroy the exocrine glands, specifically the salivary and lacrimal glands that produce saliva and tears, respectively. The detection method measure the magnetic label of an immunoassay which is an alternative to the traditional enzyme-linked immunosorbent assay. This study is divided into two parts namely: the design and verification of the hall sensor, and the development and interfacing of the hall sensor array with the readout circuit. This work uses the semiconductor manufacturing process that is compatible to the development of a hall sensor array to increase the sensor’s sensitivity. The magnetic signal through the hall sensing array is converted to electrical signals per sensor unit to avoid field cancellation; this unit being activated by a hall switch circuit; the signal is then coupled to the read-out circuit for subsequent signal processing. The readout circuit includes a bandgap reference circuit, an oscillator, a current mode chopping instrumentation amplifier. Both circuits are described in this paper includes circuit design, layout and simulation. The readout chip hybrid circuitries and the hall sensor array with the magnetizing coils have been fabricated on-chip using TSMC 0.18 μm 1P6M CMOS technology. Furthermore, results of the on-chip tests have been presented with the measurement test benches utilizing a magnetic bead environment.

並列關鍵字

Sjögren’s syndrome, Magnetic nanoparticles, Hall sensor, Sensor array, Bandgap reference circuit, Current mode chopping instrumentation amplifier, Low pass filter

參考文獻

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磁性感測陣列及生物檢測系統電路設計

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