軌對軌運算放大電路與十二位元類比數位轉換器設計之生醫訊號應用研究

Rail-to-Rail Operational Amplifier and 12-bits Analog-to-Digital Converter Design for Biomedical Signal Application Research

徐潔茹(Jie-Ru Xu)

指導教授 ： 鍾文耀

中原大學/電機資訊學院/電子工程研究所/碩士(2018年)

https://doi.org/10.6840/cycu201800645

摘要

應用於生醫領域之互補式金氧半CMOS晶片技術與系統整合IC的開發，是新創醫材的一大利基點。但基於生醫訊號的微弱與低頻特質，且又容易受到臨床使用環境的雜訊影響，因此在醫材的研發中，擁有高性能的前端處理單元，以進行生醫訊號的放大、濾波、雜訊抑制、去除與類比數位轉換，是得到精確與可靠之有效訊號的關鍵。
本研究針對X光影像處理單元需求，進行互補式金氧半(CMOS)晶片類比運算放大關鍵電路設計及類比數位轉換器相關之生醫訊號感測應用研究。軌對軌放大器增益為84dB、共模輸入範圍0.7V~3.3V、輸出擺幅0.02V~3.27V，循環漸進式類比數位轉換器為12位元、取樣速率3MHz。
將上述兩種設計，依據X光影像處理單元需求，進行模擬與驗證，期望能透過先進製程技術下線驗證CMOS晶片的研究成果，作為未來發展CMOS生醫感測電路的發展技術參考，提高未來實驗室在新創醫材相關應用電路開發的自主性與掌握度。

關鍵字

互補式金氧半電晶體 ； X光影像處理單元 ； 生醫感測 ； 軌對軌放大器 ； 循環漸進式類比數位轉換器 ； 類比佈局

並列摘要

The development and integration of Complementary Metal Oxide Semiconductor (CMOS) Integrated Circuit (IC) chip technology for use in the biomedical field is a major advantage for new medical applications. However, based on the weak and low-frequency characteristics of the biomedical signal, it is susceptible to the noise of the clinical environment. This paper focus on the study of the medical device that has a high-performance front-end processing unit for amplification, filtering, noise repression, removal, and analog digital conversion which are the keys to accurate and reliable signals.
This study focus on CMOS amplification and analog to digital converter related biomedical signal sensing application research, specifically on X-ray image processing. The design and implementation of two circuits namely rail-to-rail amplifier and a successive approximation analog to digital converter is designed to achieve low noise, low power, high common-mode rejection ratio, power supply rejection ratio, and high-resolution analog-digital conversion.
The above two circuits are simulated and verified according to the requirement of the X-ray image processing unit. The main contribution of the study is that the circuit is designed for image processing which is novel. This technology can used in advanced process technology for verification, and for technical reference for more accurate X-ray image processing analysis for further development of CMOS biomedical sensing circuits.

並列關鍵字

CMOS ； X-ray image unit ； Biomedical sensing ； Rail-to-Rail amplifier ； Successive approximation analog to digital converter ； Analog layout

參考文獻

[1] 中科院產學科技服務網 “醫療診斷x光立體影像感測器關鍵技術開發104/105年成果,” http://www.csistdup.org.tw/projectitemlist.aspx?n=7&id=96, 2017/01/05。

[2] 中科院醫用X光直接讀取式數位X光感測器成果展，2016/12/23龍潭。

[3] H. Mori, et. al., “LARGE FORMATTED AND HIGH RESOLUTION CMOS FLAT PANEL SENSORS FOR X-RAY,” The 8th International Conference of the Slovenian Society for Non-Destructive Testing, September 1-3, 2005, Portorož, Slovenia, pp. 165-172.

[4] Wei-Yen Lee,; Cheng-Wei Sun; Yung-Hsiang Chiu,“X-RAY ACTIVE PIXEL SENSOR (APS) READOUT CIRCUIT AND READOUT METHOD”, U.S. Patent No.8586940 B2, Nov.19, 2013.

[5] Myung' Jln Soh, Langley; Seul-Yi Soh, Langley,“PARALLEL MODE READOUT INTEGRATED CIRCUIT FOR X_RAY IMAGE SENSOR,’ U.S. Patent No.8729485 B2, May. 20, 2014.