低雜訊儀表放大器結合線性陣列型生物感測器之讀出電路積體設計

使用線性陣列型生物感測器的目的有幾點：1.可同時感測不同之待測物，增加感測器之多功能性。2.若一個感測器損壞，還能繼續感測待測物。3.提高訊號雜訊比，未來可應用在感測濃度較低之待測物。本論文之關鍵零組件為低雜訊儀表放大器，且利用軌對軌運算放大器並加入啟動電路來完成之。再藉由CIC提供之TSMC CMOS 0.35um 2P4M製程技術完成晶片之設計，接著結合生物感測器來驗證電路之可行。在量測部分，量測出感測器窗口大小與雜訊成正比。同時也驗證出可利用類比多功器降低成本。並且，在實驗過程中也量測到訊號雜訊比提高。最後，再利用類比多功器來選擇感測訊號，並在實驗中驗證出讀出電路可結合線性陣列型生物感測器。

關鍵字

訊號雜訊比；儀表放大器；軌對軌運算放大器；線性陣列型生物感測器

並列摘要

There are some purposes of using linear-array biosensors. 1.It can sense different analytes at the same time. 2.If one of sensors is broken, others can sense analytes. 3.It can increase SNR and so it can be used in analyte with low concentration. The key component of this paper was to design a low noise instrumentation amplifier. It was used rail-to-rail operational amplifier and added star-up circuit. After completing the design of the chip by using the TSMC CMOS 0.35um 2P4M manufacture technology that was provided by CIC, we verified the feasibility of the circuit by combining the biosensor. In measurement, we found that the sensor noise was reduced with the window size. By the use of MUX, the cost can be reduced. It was found that SNR was increased. Finally, the feasibility of combining linear-array biosensors by using MUX was verified.