Lithium battery pole piece manufacturing can be divided into four steps: mixture, coating, rolling and cutting. The case study production company in order to manufacture the pole piece mixture, will need to input 55 X process parameters and 14 Y inspection values. If the pre-process or inspection is not completed then pass to the next process, it will cause the post-process to produce defective products and reworks. This study is to design a manufacturing execution system based on Li-Battery pole piece production system development, which will not let the post-process start self inspection before the former process is completed, this will prevent human error and by parameter to manage the system will make the right formula into production, also the data for inspection will bring the result rapidly which can prevent defective productions and reworks. The Li-Battery pole piece production yield rate will improve at least 2% after the case study production company to apply this system.