多孔性含氟水膠之製備與性質研究

STUDIES ON PREPARATION AND PROPERTIES OF POROUS HYDROGELS CONTAINING FLUORINATED MONOMERS

劉大銘(Ta-Ming Liu)

指導教授 ： 李文褔

大同大學/工程學院/化學工程學系所/碩士(2004年)

摘要

研究三種含氟疏水性單體，2,2,3,3,4,4,5,5- Octafluoropentyl methacrylate (OFPMA)、4,4,5,5,6,7,7,7-Octafluoro- 2-hydroxy-6- (trifluoromethyl) heptyl methacrylate (OFHHMA) 或3,3,4,4,5,6,6,6- Octafluoro-5-(trifluoromethyl) hexyl methacrylate (OFHMA) 與N-isopropylacrylamide (NIPAAm)於水溶液中以乳化聚合法聚合之共聚合膠體。所以在本篇文章中我們討論於疏水性單體與同時是界面活性劑與成孔劑的SLS量的變化於平衡膨潤度與機械性質的影響。結果顯示含氟疏水單體使膨潤度下降而使機械強度提升，而SLS則造成相反的結果。此外我們亦研究含氟單體對藥物釋放的影響。
N-isopropylacrylamide (NIPAAm)與含氟單體2,2,3,3,4,4,5,5- Octafluoropentyl methacrylate (OFPMA)、4,4,5,5,6,7,7,7-Octafluoro- 2-hydroxy-6-(trifluoromethyl) heptyl methacrylate (OFHHMA) 或3,3,4,4,5,6,6,6-Octafluoro-5-(trifluoromethyl) hexyl methacrylate (OFHMA)再與poly(ethylene glycol)methylether acrylate (PEGMEA, EO=9)以乳化聚合法聚合得一系列二成份與三成份的共聚合水膠。我們將研究PEGMEA的導入對其膨潤動力、機械性質與藥物釋放性質。結果顯示PEGMEA的導入有助於膨潤度與機械強度的提升。除此之外我們也研究此組膠體其藥物釋放性質。
以溶液聚合法聚合以SLS與NaHCO3為成孔劑製備多孔性NIPAAm水膠。我們研究成孔劑對多孔水膠在膨潤性質與藥物釋放的影響。結果顯示成孔劑的加入有助於水膠膨潤度的提升，其中又以兩步驟成孔的水膠比一步驟成孔的水膠在成孔劑SLS與NaHCO3具有較明顯的影響。在藥物釋放性質上以兩步驟成孔水膠其caffeine與vitamin B12釋放動力的釋放趨勢皆為NN>N>NSN>NS。最後我們可以從SEM的形態上看出一步驟成孔與兩步驟成孔水膠的區別。

關鍵字

多孔 ； 水膠 ； 疏水性 ； 氟 ； 聚乙二醇甲基醚丙烯酸酯 ； 碳酸氫鈉 ； 十二烷基磺酸鈉 ； 藥物釋放性質

並列摘要

Three series of copolymeric gels based on N-isopropylacrylamide (NIPAAm) and perfluoroalkyl methacrylate such as 2,2,3,3,4,4,5,5- octafluoropentyl methacrylate (OFPMA), 4,4,5,5,6,7,7,7-octafluoro-2- hydroxy-6-(trifluoromethyl)heptyl methacrylate (OFHHMA) and 3,3,4,4,5,6,6,6-octafluoro-5- (trifluoromethyl)hexyl methacrylate (OFHMA), were prepared by emulsion polymerization. The effect of perfluoroalkyl methacrylate and sodium lauryl sulfate (SLS), which can act as a surfactant and a pore-forming agent, on the equilibrium swelling ratio and mechanical properties of the present hydrogels was investigated. Results show that hydrophobic monomers made the swelling ratio of the gel decrease and the mechanical property of the gel increase; however SLS exhibits a contrary result. In addition, the effect of perfluoroalkyl methacrylate on the drug release behavior was also investigated.
Two series of copolymeric hydrogels based on N-isopropylacrylamide (NIPAAm) and perfluoroalkyl methacrylate such as 4,4,5,5,6,7,7,7-octafluoro-2-hydroxy-6-(trifluoromethyl) heptyl methacrylate (OFPMA), 4,4,5,5,6,7,7,7-octafluoro-2- hydroxy-6-(trifluoromethyl) heptyl methacrylate (OFHHMA), 3,3,4,4,5,6,6,6-octafluoro-5-(trifluoromethyl) hexyl methacrylate (OFHMA) and/or poly(ethylene glycol)methylether acrylate (PEGMEA, EO=9) were prepared by emulsion polymerization. The effect of PEGMEA on the swelling ratio and mechanical properties of the present copolymeric gels was investigated. Results show that the swelling ratio and mechanical property for the present copolymeric gels increase with the incorporation of PEGMEA into the NIPAAm and perfluoroalkyl methacrylate copolymeric gels. In addition, the drug release behavior of the present copolymeric gels was also investigated.
A series of porous poly(NIPAAm) gels were prepared by adding porosigens, such as sodium lauryl sulfate (SLS) and sodium bicarbonate (NaHCO3), by water solution polymerization. The effect of pore-forming method on the swelling and drug release behavior for the porous poly(NIPAAm) hydrogels was investigated. Results showed that adding porosigen into the gel-forming process would increase the swelling ratios of the porous gel, and the swelling ratios for the porous gel formed by two-step process shows a more significant distinction between SLS and NaHCO3 than one-step process. In drug release behavior, the releasing dynamic of caffeine and vitamin B12 for the gels forming by two-step process showed a tendency of the release ratios of the caffeine and vitamin B12 in the order NN>N>NSN>NS. Finally, we also took SEM pictures to see morphological distinction for the gels formed by one-step and two-step process.

並列關鍵字

Drug releasing behavior ； Fluorine ； Hydrogel ； Hydrophobic ； NaHCO3 ； PEGMEA ； Porous ； SLS

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