血液透析用液之內毒素監測－內毒素檢測趨勢與經驗分享

血液透析患者長期處於免疫功能不全狀態，加上現今廣泛使用高通透透析器（high-flux dialyzers）時產生之逆過濾（backfiltration）現象，皆會增加血液透析患者的系統性發炎與感染風險。若透析用液中存在過量之細菌或內毒素（endotoxin），可能會引發透析患者發燒、發炎反應、甚至感染，影響透析安全及患者預後。本文簡介內毒素與強調其在透析用液中的監測重要性，並簡述目前內毒素檢測方法的趨勢，文末也提供筆者任職透析單位近年內之內毒素監測成果。

關鍵字

透析用液；內毒素；鱟試劑；重組因子C

並列摘要

The increased risk of systemic inflammation and infection in hemodialysis patients is contributed by long-term immunocompromised status as well as backfiltration during hemodialysis with commonly used high-flux dialyzers. Excessive bacteria or endotoxins in dialysis fluid may cause fever, inflammatory response, and infection, which have impacts on dialysis safety and patient outcomes. This article briefly introduces endotoxin, emphasizes the importance of endotoxin monitoring in dialysis fluid, gives a description of current trends in bacterial endotoxin tests, and provides our experience and results of endotoxin monitoring in recent years.

並列關鍵字

dialysis fluid ； endotoxin ； limulus amebocyte lysate ； recombinant factor C

國際替代計量

血液透析用液之內毒素監測－內毒素檢測趨勢與經驗分享

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