- 期刊
Sinonasal Undifferentiated Carcinoma
鼻腔鼻竇未分化細胞癌
摘要
鼻腔鼻竇未分化細胞癌是一種罕見且侵犯性很高的鼻腔及鼻竇惡性腫瘤。臨床表現主要以顏面疼痛、鼻塞、流鼻血、眼瞼下垂或視力減退等來表現，雖經積極治療如手術切除加上放射線治療或化學治療，其預後還是不好，很快就發生局部復發或遠隔轉移的現象。其存活率由臨床診斷至死亡皆為數個月到十幾個月。本院於2002年5月經歷一名51歲女性病人，主訴右側嚴重鼻塞、右側臉頰腫脹有3個月之久，經電腦斷層檢查發現為右側鼻腔鼻竇腫瘤併眼球後侵犯。病人接受右側上頷竇全切除，術後並追加化學治療及放射線治療，至今並無局部復發或遠隔轉移等現象。病理檢查報告為鼻腔鼻竇未分化細胞癌。鼻腔鼻竇未分化細胞癌為一種罕見的惡性腫瘤，治療上至今仍無定論，手術、放射線和化學治療三者合併治療是必須的，但其預後仍然很差，因病例罕見，特提出報告。
並列摘要
Sinonasal undifferentiated carcinoma is an uncommon aggressive malignancy of the nasal cavity and the paranasal sinuses. Symptoms include facial pain, nasal obstruction, epistaxis, proptosis, and decreased visual acuity. Despite aggressive therapy combining radical resection, radiotherapy, and chemotherapy, the outcome remains dismal, with the post-diagnosis mean survival time being less than one year. We present a 51-year-old female whose chief complaints were progressive nasal congestion, pain in the right maxillary region, prolonged headache, and decreased vision in the right eye. Computed tomography imaging revealed a tumor mass that filled the right nasal cavity and extended to the right maxillary sinus and the posterior part of orbit cavity. Nasal tumor biopsy showed a sinonasal undifferentiated carcinoma; the patient was treated by right side medial maxillectomy. Sinonasal undifferentiated carcinoma was confirmed. The patient received three cycles of chemotherapy and radiotherapy after the surgery. No recurrence was evident at an 18 month follow-up examination.
延伸閱讀
- 簡淑琦、王國榮（1994）。鼻腔及鼻竇之倒生性乳頭狀瘤併惡性淋巴瘤－病例報告。中華民國耳鼻喉科醫學會雜誌，29(2)，124-128。https://doi.org/10.6286/1994.29.2.124
- 劉哲宏、呂宜興、陳碧芳、李國森（1997）。鼻竇鼻腔惡性血管外皮細胞瘤－病例報告。中華民國耳鼻喉科醫學會雜誌，32(2)，197-200。https://doi.org/10.6286/1997.32.2.197
- 陳咸伸、袁本治、翁慧卿、錢尚道（2007）。鼻腔原發瀰漫性大B細胞淋巴瘤。台灣耳鼻喉頭頸外科雜誌，42(6)，206-210。https://doi.org/10.6286/2007.42.6.206
- 陳鴻鑫、李佳茹、黎瓊柱、蔡青劭（2009）。鼻－鼻竇之漿細胞瘤。台灣耳鼻喉頭頸外科雜誌，44(5)，155-159。https://doi.org/10.6286/2009.44.5.155
- 翁英哲、林清榮、李永賢、張斌（1992）。鼻腔及鼻竇之腺樣囊狀癌。中華民國耳鼻喉科醫學會雜誌，27(4)，328-334。https://doi.org/10.6286/1992.27.4.328