Epidermoid cysts occur when embryonic development goes slightly awry. Although they have been found in most parts of the body, the oral cavity is nevertheless a rarely involved site. We treated a 28-year-old female patient who described an intro-oral mass that had progressively enlarged over eight years, resulting in snoring, swallowing difficulties, and respiratory distress. On examination, a large tumor was seen emerging from the floor of the mouth and pushing the tongue posteriorly so as to nearly obstruct the oropharynx. Computed tomography depicted a large cystic mass of homogeneous and hypodense content. The patient underwent complete excision of the mass. The capsule remained intact and the size the specimen was 6×6×7 cm. Tissue pathology identified the mass as an epidermoid cyst. Symptoms were markedly relieved postoperatively and there was no recurrence over a six month follow-up period. Accordingly, an epidermoid cyst should be included in the differential diagnosis of any cystic lesions of the floor of the mouth, and complete excision of such tumors is indicated.