Neurilemmoma (also known as Schwannoma, Schwann's cell tumor, lemmoma, neurinoma, neurolemmoma, and peripheral fibroblastoma) is a benign tumor of peripheral nerve sheath origin. These lesions may occur at any location which grow extremely slowly, and are usually asymptomatic. Most of the tumors had been present for a long period before diagnosis. Treatment by surgical excision is considered adequate. Recurrence is uncommon and malignant change is said to be rare. In September 1996, a 26-year-old female complained of a painless swelling in the right anterior mouth floor. It increased in size slightly in the past one year without any discomfort. The tumor was excised intactly. The histopathology showed typical picture of neurilemmoma with well encapsulated. The diagnosis was also confirmed by the immunohistochemical staining of the tumor cells with S100 protein. Neurilemmoma occurring in the mouth floor is rare, we hereby present a case experience for clinical consideration when encountering a mass in the mouth floor.