The nanograde titanium dioxide (TiO2) is explored by UV light to exhibit a strong bactericidal activity. In this study, nylon fabrics were treated with nanograde titanium dioxide particles, which can be photocatalyzed by UV light in proportion to the irradiation time under a variety of conditions. The effects of antibacterial and physical properties in treated nylon fabrics has been investigated. The results show that in the treated nylon fabrics were less damaged by both Gram(+) bacteria and Gram(-) bacteria cells after TiO2 photocatalytic reaction. The antibacterial effects increases with the TiO2 concentration and UV irradiation time. Another, the strength and softness of Nylon fabrics treated with nanograde titanium dioxide were better after UV irradiation.