Basing on previous literatures belonged to the crucial factors on the adoption of innovation technology, this paper considered organizational operation, industry environment, and customer relationship management dimensions, and used a survey to investigate the factors influencing adoption of CRM in health examination department of hospital. A total of 87 questionnaires were mailed and 50 returned efficaciously. The response rate was 57.47%. Discriminant analysis was employed to test those nine hypotheses. The results reveals that important factors such as operation cost, formalization, compatibility and relative advantage, and interdepartmental integration would affect the adoption of CRM in health examination department of hospital.