Nephropathy and Heroin Addiction

腎病與海洛因成癮

陳志剛(Chih-Kang Chen) ； 陳志倫(Chih-Lun Chen) ； 林裕峰(Yuh-Feng Lin) ； 陳益乾(Yi-Chyan Chen)

《台灣精神醫學》 19卷2期 (2005/06) Pp. 148-153

https://doi.org/10.29478/TJP.200506.0008

摘要

目的：海洛因成癮爲慢性且易復發的精神科疾患，常導致身體器官的傷害。關於海洛因成癮相關腎病的研究報告仍相關有限，本文報告二例海洛因成癮相關之嚴重腎病症候群。病例報告：二病例之腎臟病理切片皆爲微小病變性腎病，其獨特臨床病徵爲於海洛因成癮後短時間內即併發腎病變且合併嚴重蛋白尿症，爲文獻中所罕見。結論：海洛因成癮行爲會合併嚴重的腎病症候群，其病因學機制包含複雜的因素，如海洛因直接或間接誘發的腎病變、海洛因添加物造成的腎毒性、及C型肝炎病毒誘發的免疫反應，另外國人生物體質的異質性及環境因素的差異性，是另一值得探究的問題。精神科治療海洛因成癮有助於此類患者之預後。

關鍵字

海洛因成癮 ； 腎病症候群 ； 添加物 ； C型肝炎

並列摘要

Objective: Heroin addiction is a chronic and relapsing psychiatric disorder, characterized by compulsive seeking and use of heroin. Among the diverse medical complications associated with heroin addiction, heroin-related nephropathy is relatively uncommon. We report two cases of severe nephrotic syndrome with poor clinical outcome in patients with heroin addiction. Case reports: Both of these patients with heroin-related nephropathy presented with several distinct clinical features, including a very short duration of heroin addiction before the development of the renal disease and profound proteinuria. These complications have not been previously reported. Conclusion: Heroin addiction can cause profound nephrotic syndrome. The development of nephropathy in heroin addicts has a multifactorial etiology, including heroin-mediated effects, the effects of adulterants mingling with heroin, hepatitis C, as well as possible ethnic variations which may be influenced by genetic and environmental factors. Early psychiatric intervention is essential to deter hazardous addictive behavior and to prevent the development of heroin associated nephropathy.

並列關鍵字

heroin addiction ； nephrotic syndrome ； adulterant ； hepatitis C

參考文獻

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