- 期刊
The Association of GSTT1 Genetic Polymorphism with the Risk of Esophageal Cancer-Interactive with Environmental Exposure
並列摘要
In this study, we investigated the association of the genetic polymorphisms of CYPlAl, CYP2E1, GSTMl and GSTTl with the risk of esophageal cancer in Taiwan. We recruited 105 cases of esophageal squamous cell carcinoma and 266 persons of healthy controls during 1996-1999. The genotypes of the xenobiotic metabolizing enzymes were determined by PCR or PCR-RFLP. There was no significant difference in distribution of these genotypes between the patients and controls. However, among the cigarette smokers, GSTTl null genotype was found to associate a higher risk of esophageal cancer, after adjustment with other environmental confounders (OR: 2.44;95% CI:1.17-5.08). Our results revealed that the GSTTl genetic polymorphism might interact with cigarette smoke to modulate the risk of esophageal cancer in Taiwan.
延伸閱讀
- 陳韻如（2005）。Interactive Effects of Lifetime Alcohol Consumption and Alcohol and Aldehyde Dehydrogenase Polymorphisms on Esophageal and Gastric Cancer Risks〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-2903200614024754
- 吳俊德、邱幼青、林鍚慧、戴火木、石東生、張火炎（2006）。Effects of Genetic Polymorphism of CYP2E1 and GST on Urinary Biomarkers of Occupational Exposure to N,N-dimthylformamide。勞工安全衛生研究季刊，14(4)，253-263。https://doi.org/10.7005/JOSH.200612.0253
- 張宜欣（2008）。Interaction among genetic polymorphism, dioxins/PCBs, and phthalate monoesters in the risk of estrogen-dependent diseases〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-2808200800275500
- Xue, W. (2004). Molecular cytogenetic, epigenetic and tissue dynamic study of gestational trophoblastic disease [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200018133
- Yan, Z., Luke, B. T., Tsang, S. X., Xing, R., Pan, Y. M., Liu, Y. X., Wang, J. L., Geng, T., Li, J. G., & Lu, Y. Y. (2014). Identification of Gene Signatures Used to Recognize Biological Characteristics of Gastric Cancer Upon Gene Expression Data. Biomarker Insights, 2014(), 67-76. https://doi.org/10.4137/BMI.S13059