Mitomycin-C在翼狀贅片治療上的運用

The Application of Mitomycin C in the Treatment of Pterygium

鄭惠川(Huey-Chuan Cheng) ； 汪正光(Cheng-Kuang Wang)

《中華民國眼科醫學會雜誌》 37卷1期 (1998/03) Pp. 35-42

https://doi.org/10.30048/ACTASOS.199803.0008

摘要

即使已有相當多藥物或手術的治療方式被發表過，復發仍是翼狀贅片治療上最大的隱憂。所以在使鞏膜裸露的簡單切除之外，不斷地有許多更有效的附加治療方式被發表過，Mitomycin C即是其中一種；本報告的目的即在比較Mitomycin C與其他附加治療的效果。對於初次復發的翼狀贅片，我們比較了Mitomycin C與結膜瓣移植的效果，結果顯示術中單次使用Mitomycin C與結膜瓣移植的術後復發率並不具統計上有意義的差異(P=0.09)；而對於原發性翼狀贅片，我們則比較了Mitomycin C與Thio-tepa的效果，結果顯示術中單次使用Mitomycin C與Thio-tepa術後點眼的復發率具有統計上有意義的差異(P=0.02)。另一方面，在本報告中所有使用Mitomycin C的病例皆未見嚴重的併發症。藉向這個研究結果，我們認為對於復發性的翼狀贅片術中單次使用Mitomycin C與結膜瓣移植的效果並無差異；而對於原發性翼狀贅片術中單次使用Mitomycin C 則較Thio-tepa術後點眼有效。

並列摘要

A number of adjunctive therapies have been employed to decrease the risk of recurrence after surgical removal of a pterygium. The intraoperative application of mitomycin C is one of these methods. This prospective, randomized study was carried out in two parts. The efficacy of mitomycin C was compared with that of conjunctival autograft in the management of recurrent pterygia, but no sifnificant difference (P=0.09) was found between them. While the efficacy of mitomycin C was compared with that of topical thio-tepa in the treatment of primary cases, the result revealed statistically significant difference (P=0.02). In addition, there is no serious complication after the application of mitomycin C. Therefore, we concluded that there was no difference in the efficacy between mitomycin C and conjuntival autograft in the treatment of recurrent pterygia. But on the other hand, the intraoperative application of mitomycin C was superior to topical thio-tepa as an adjunctive therapy in the surgical excision of primary pterygia for Chinese patients.

並列關鍵字

Conjunctival autograft transplantation ； Mitomycin C ； Recurrent pterygium ； Thio-tepa