”Triple realms existing only in minds” and ”Big-Bang cosmology” are two kinds of hypothesis about the birth of the cosmos respectively presented by Buddhism and Science. In exploration of the universe's birth, these two different systems amazingly share the similar induction that the cosmos is generated from vanity. Nevertheless, there remain some discrepancies in the so-called ”vanity” held by both ends: the one from science has nothing to do with ”mind” while the one from Buddhism is related with ”mind”. Again, the conclusion induced by Buddhism could be further experienced through cultivation; yet science could not verify it with experimental approach.