- 期刊
Chronic Hemodialysis Patients with Visceral Obesity Have a Higher Risk for Cardiovascular Events
血液透析患者的內臟型肥胖和心血管併發症風險相關
摘要
血液透析患者罹患心血管疾病的風險相當高。透析患者罹患心血管疾病的危險因子包括年齡、營養不良、透析治療持續時日、糖尿病及高血磷。然而，透析患者腹部肥胖與心血管疾病的關係並不清楚。本研究的目的即在釐清長期透析患者內臟脂肪面積和心血管併發症的關係。利用電腦斷層掃描測量94位患者的內臟脂肪面積，並且評估這些患者的腹部主動脈鈣化指數（ACI）、血脂肪和心血管併發症。與內臟脂肪面積少於100 cm^2的患者相比，內臟脂肪面積較大（≥100 cm^2）的患者，其心血管併發症和血清三酸甘油酯顯著較高，且高密度脂蛋白膽固醇顯著較低。內臟脂肪面積較大且長期接受透析治療的患者，其ACI分析結果較嚴重，且缺血性心臟病發病率較高。這篇研究結果顯示內臟脂肪面積較大的慢性透析患者，其心血管疾病風險較高，特別是缺血性心臟病。
並列摘要
The risk of cardiovascular disease is substantially high in hemodialysis patients. The risk factors for cardiovascular disease in dialysis patients include age, malnutrition, duration of dialysis, diabetes mellitus and hyperphosphatemia. However, it is not clear whether cardiovascular disease is associated with abdominal obesity in dialysis patients. The aim of the present study was to clarify the relationship among visceral fat area and cardiovascular complications in chronic dialysis patients. Area of visceral fat was measured using computed tomography scan in 94 patients. The abdominal aortic calcification index (ACI), blood lipid profile and complication of cardiovascular disease were evaluated in these patients. Compared to patients with smaller visceral fat area (＜100 cm^2), those with larger visceral fat area (≥100 cm^2) showed significantly higher cardiovascular complication and higher serum levels of triglyceride and significantly lower serum levels of HDL-cholesterol. Patients with larger visceral fat area and longer duration of dialysis showed severer calcification by ACI analysis, and showed higher incidences of ischemic heart disease. This study suggested that chronic dialysis patients with higher visceral fat area have a higher risk for vascular events, especially ischemic heart disease.
延伸閱讀
- Kuo, C. F., Lin, J. T., Chen, J. C., Sheu, J. C., Huang, G. T., Yang, P. M., Chen, D. S., Wang, T. H., Su, I. J., & Sung, J. L. (1987). 糖尿病及高脂血症併發肝臓之局部脂肪浸潤：一例報告. 中華民國消化系醫學會雜誌, 4(2), 72-76. https://doi.org/10.6557/GJTa.198706_4(2).0005
- 林韋臣（2008）。減重介入與肥胖指標對於心血管疾病危險因子及細胞激素的影響〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://doi.org/10.6832/KMU.2008.00135
- 李宗澔（2020）。肥胖指標與糖尿病、高血壓與高血脂症遺傳傾向之關聯性〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU202002854
- 黃淑君（2009）。過重者及肥胖者的身體活動與代謝症候群、高血壓前期及糖尿病前期的關係探討〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-2007200916491200
- 陳柏志、梁景超、劉志龍、潛詡涵（2016）。血液中脂聯素和高敏感度C反應蛋白濃度與心血管疾病的相關性探討。台灣醫檢雜誌，31(3)，15-23。https://www.airitilibrary.com/Article/Detail?DocID=P20140729002-201609-201610240005-201610240005-15-23