Associations of Decreased Serum Transthyretin with Elevated High-Sensitivity CRP, Serum Copper and Decreased Hemoglobin in Ambulatory Elderly Women

老年女性血清甲状腺素降低与升高的高敏C反应蛋白和血清铜以及降低的血红蛋白之间的关系

Ayaka Tsuboi ； Mayu Terazawa-Watanabe ； Tsutomu Kazumi ； Keisuke Fukuo

《Asia Pacific Journal of Clinical Nutrition》 24卷1期 (2015/03) Pp. 83-89

https://doi.org/10.6133/apjcn.2015.24.1.18

摘要

背景：甲状腺运载蛋白（TTR）是反映营养不良和炎症的一个敏感指标，已被证实与老年人口死亡率有关。方法：我们研究了185名独立生活的老年妇女血清TTR和一系列死亡风险因素之间的关系。血液在早餐和午餐之间抽取。结果：TTR与年龄呈负相关（r=-0.30,p＜0.001）。在控制了年龄因素后，TTR与高敏C反应蛋白（hsCRP）的对数和血清铜呈负相关，与白蛋白、血清铁、血红蛋白呈正相关。此外，TTR与收缩压、舒张压、餐后甘油三酯（TG）呈正相关。在以TTR为因变量的多元回归分析中，独立于年龄、白蛋白、血清铁、收缩压和舒张压，血红蛋白（标准化β, 0.244）、血清铜（标准化β, - 0.134）、餐后TG（标准化β, 0.223）和高敏C反应蛋白对数（标准化β, 0.190）解释了TTR变率的22.8%。结论：亚临床轻度炎症，升高的血清铜和降低的血红蛋白可能与日本社区老年妇女血清TTR下降有关，并且有可能是老年人低浓度TTR和死亡率关系的混杂因素。TTR与餐后TG值的相关性有待进一步研究。

關鍵字

铜 ； 轻度炎症 ； 血红蛋白 ； 餐后甘油三酯血症 ； 甲状腺素

並列摘要

Background: Transthyretin (TTR), a sensitive indicator of malnutrition and inflammation, has been shown to be associated with mortality in elderly population. Methods: We examined relationships between serum TTR and a range of risk factors for mortality in 185 free-living elderly women. Blood was drawn between breakfast and lunch. Results: TTR was correlated negatively with age (r=-0.30, p＜0.001). After controlling for age, TTR was negatively associated with log high-sensitivity CRP (hsCRP) and serum copper. It was positively associated with albumin, serum iron and hemoglobin. In addition, TTR was positively correlated with systolic and diastolic blood pressure and postprandial triglyceride (TG). In multiple regression analysis for TTR as a dependent variable, hemoglobin (standardized β, 0.244), serum copper (standardized β, -0.134), postprandial TG (standardized β, 0.223) and log hsCRP (standardized β, -0.190) emerged as determinants of TTR independently of age, albumin, serum iron, systolic and diastolic blood pressure, and explained 22.8% of TTR variability. Conclusions: Subclinical low-grade inflammation, elevated serum copper and decreased hemoglobin were associated with decreased serum TTR in community-living elderly Japanese women and may represent important confounders of the relationship between low TTR and mortality in the elderly. The positive association of TTR with postprandial TG warrants further investigation.

並列關鍵字

copper ； low-grade inflammation ； hemoglobin ； postprandial triglyceridemia ； transthyretin