Advances in medical technology and the rapid increase of medical knowledge have been able to improve health care quality as well as provide efficient health service. Evidence-based nursing has become the essential ability among clinical nurses. However, the literature shows that currently in Taiwan evidence-based school nursing is lack of relevant studies. Further, the concept of evidence-based nursing is well-developed in acute or chronic medical rehabilitation based, but there is no publication in the health promotion field in school nursing. This article describes the importance of application evidence-based nursing practice at school, including development of evidence-based nursing practice, capability of evidence-based nursing and factors associated with evidence-based nursing. This paper provides guidance for developing evidence-based school nursing.