Although right hemicolectomy is not a difficult procedure, sometimes, portal vein thrombosis can lead to postoperative complications, resulting in significant procedure-related morbidity and mortality. The etiology of portal vein thrombosis is unclear. In this case report, a patient with locally advanced appendiceal cancer underwent right hemicolectomy via the open approach, following which there was an unexpected complication due to portal vein thrombosis. However, the patient made a full recovery after appropriate treatment.