Tooth transposition is a dental anomaly characterized by the exchange in position of 2 or more teeth within a quadrant of the dental arch. Although the mechanism of tooth transposition is not clear, it seems to be closely related to genes or retained primary tooth or trauma. Maxillary permanent canine usually transposes with the first premolar and occasionally with lateral incisor. Tooth transposition is a big challenge for many dentists. The present case report describes a situation where the left canine to the left first premolar complete transposition was present along with a congenital missing left lateral incisor and the peg-shaped right lateral incisor. After a period of one and half year of the orthodontic treatment, we had performed prosthodontic treatment. The article will discuss the prevalence, clinical diagnosis and the orthodontic, prosthodontic treatment.