結合酵素場效電晶體與微閥門之葡萄糖感測技術

The development of a glucose sensor chip using Enzyme-based FETs and micro-valves

陳彥志(Yen-Chih Chen)

指導教授 ： 呂志誠

國立臺北科技大學/機電學院/機電整合研究所/碩士(2009年)

https://doi.org/10.6841/NTUT.2009.00211

摘要

本論文提出新式血糖量測方式，將微型血糖計與微流道檢測系統整合，使用標準CMOS製程外加客製化後製程，可望成為微全分析系統(u-TAS, micro-total analysis system)，實現多功能及低成本之新式檢測系統。新式感測器可分成兩大部分，微型血糖計、微閥門致動器與微流道，本研究將先完成微型血糖計及微閥門為主要目標；微型血糖計係採用離子感應場效電晶體(Ion-Sensitive FET, ISFET)，其對於溶液酸鹼度與汲極電流正相關之特性，加上特定葡萄糖氧化酵素(glucose oxidase, GOD)，轉化血糖濃度為酸鹼度，進而影響溶液酸鹼度和汲極電流，達成血糖量測之目的；微閥門致動器為靜電力驅動，與玻璃基板上之微流道可形成封閉系統，可大幅增加微型血糖感測器之可靠度與精準度。血糖檢測晶片與標準製程相容，在未來可將無線射頻電路整合於感測器中，冀望用於體內植入，達成三大方向：高生物相容性、即時體內血糖濃度、無線感測之量測過程。

關鍵字

離子感應場效電晶體 ； 葡萄糖氧化酵素 ； 微流道 ； 微閥門

並列摘要

This paper presents a novel method to detect glucose concentration against traditional ones. We integrate glucose sensor with channel measurement system on single silicon chip. It could be a micro-total analysis system (μ-TAS). It carries out low-cost and multi-function examining device.
The novel sensor can be divided into three parts, i.e. glucose sensor, micro-valves and micro-channel. This research primary target is to design glucose sensor and micro-valve. The glucose sensor employs ion-sensitive FET (ISFET). The glucose transformation mechanism adapts glucose oxidaze (GOD) enzyme which has good selectivity on glucose. The GOD effectively transfers hydrogen ion concentration to glucose concentration. It can completely measure glucose.
Micro-valve actuator is operated by electrostatic. It can be combined with micro-channel. This system improves sensor lifetime and biocompatibility. In the future, we can integrate RF circuit in the sensor chip for in vivo implantation. We can achieve three major improvements, i.e. high biocompatibility, in vivo real time glucose concentration measurement, and wireless measurement.

並列關鍵字

ISFET ； GOD ； micro-valves ； micro-channel

參考文獻

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