Cancer-related fatigue (CRF) is one of the most common symptoms and problems faced by cancer patients, with up to 92% of cancer patients in Taiwan suffering from cancer-related fatigue. This case is a 60-year-old male gastric cancer stage IV patients, due to chemotherapy after the symptoms of fatigue to our chinese medicine clinic. The symptom belong to Spleen-Stomach Qi Deficiency in TCM concept. He treated with Si Jun Zi Tang as main remedy. His score of Brief Fatigue Inventory- Taiwanese (BFI-T) has improved from 6.3 to 2. The results are beneficial to Chinese and Western medicine to care for cancer chemotherapy patients and improve the possibility of patients' quality of life.