Gastrointestinal Uptake of Macromolecules

消化道對大分子之攝取

D. Grant Gall

《Acta Paediatrica Sinica》 39卷1期 (1998/02) Pp. 9-11

https://doi.org/10.7097/APS.199802.0009

並列摘要

Although the majority of dietary proteins undergo extensive digestion, small, nutritionally insignificant amounts of food proteins appear to cross the gastrointestinal mucosa intact. Experiments in a variety of allergic models has demonstrated that exposure of the gastrointestinal mucosa to the intact allergen leads to an anaphylactoid reaction. To examine the uptake of immunologically intact protein across the gastrointestinal epithelium, the mucosal to serosal movement of bovine serum albumin was measured in stripped gastric and intestinal mucosa mounted in modified Ussing-type chambers. Studies demonstrated that both gastric and intestinal mucosa are capable of actively transporting intact dietary proteins. In the intestine, the transport of intact molecules across the epithelium is a saturable, energy dependant process which utilizes the microtubular network and is regulated by the enteric nervous system. Transport across gastric mucosa is also dependant upon the microtublar network and is energy dependant.

並列關鍵字

macromolecular transport ； intestine ； stomach