Association and Interaction between Dietary Pattern and VEGF Receptor-2 (VEGFR2) Gene Polymorphisms on Blood Lipids in Chinese Malaysian and Japanese Adults

飲食型態和VEGFR2基因多型性間的交互作用對於馬來西亞華人和日本人的血脂之影響

Roseline Wai-Kuan Yap ； Yoshihiro Shidoji ； Wei-Min Hon ； Motofumi Masaki

《Asia Pacific Journal of Clinical Nutrition》 21卷2期 (2012/06) Pp. 302-311

https://doi.org/10.6133/apjcn.2012.21.2.19

摘要

背景/目的：飲食型態和各族群的基因多型性對於和生活型態有關的慢性疾病有不同的影響。這篇研究探討飲食型態和VEGFR2或KDR基因間的交互作用，對於兩種亞洲族群（179名馬來西亞華人和136名日本人）的心血管疾病的生理和生化上的危險因子的影響。方法：利用因素分析從飲食頻率問卷結果來找出飲食型態。藉由使用TaqMan探針的即時聚合酶連鎖反應（real-time PCR）定出rs1870377和rs2071559的基因型。生理測量有身體質量指數（BMI）、收縮壓和舒張壓。生化測量有糖化血色素和血脂（總膽固醇、三酸甘油酯、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇、總膽固醇與高密度脂蛋白膽固醇之比值）。結果：日本人的飲食型態分為日式飲食和西式飲食；馬來西亞華人的飲食型態有平衡飲食及以肉、飯和麵為主的飲食型態。對日本人而言，西式飲食和LDL-C有關，而rs2071559基因型則和HDL-C相關。對馬來西亞華人而言，以肉、飯和麵為主的飲食型態跟三酸甘油酯、HDL-C及總膽固醇/HDL-C比值有關，而rs1870377和rs2071559的基因型和總膽固醇、LDL-C有關。經過校正干擾因子後，日本人的西式飲食與rs2071559基因型間的交互作用，或馬來西亞華人的肉、飯和麵為主的飲食與rs1870377基因型間的交互作用對於血脂有明顯的效應。結論：飲食型態和VEGFR2基因間的交互作用，對於馬來西亞華人和日本人的心血管疾病的風險有不同方向的影響。

關鍵字

飲食型態 ； VEGFR2基因多型性 ； 血脂 ； 馬來西亞華人 ； 日本人

並列摘要

Background/Aims: Dietary pattern and genetic predisposition of each population have different impacts on lifestyle- related chronic diseases. This study was conducted to evaluate the association and interaction between dietary patterns and VEGFR2 or KDR gene polymorphisms on physical and biochemical risk factors of cardiovascular disease in two Asian populations (179 Chinese Malaysian and 136 Japanese adults). Methods: Dietary patterns were constructed from food frequency questionnaire using factor analysis. Genotyping of rs1870377 and rs2071559 was performed by real-time PCR using TaqMan probes. Physical measurements: body mass index, systolic and diastolic blood pressures and biochemical parameters: glycated hemoglobin A1c and blood lipids (total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol and total cholesterol/HDL-C ratio) were measured. Results: Two dietary patterns were extracted for: Japanese ('Japanese diet' and 'Western diet') and Chinese Malaysians ('Balanced diet' and 'Meat, rice and noodles diet'). In Japanese, 'Western Diet' and rs2071559 were associated with LDL-C and HDL-C, respectively. In Chinese Malaysians, 'Meat, rice and noodles diet' was associated with triglycerides, HDL-C and total cholesterol/HDL ratio while rs1870377 and rs2071559 were associated with total cholesterol and/or LDL-C. The interaction between 'Western Diet' and rs2071559 in Japanese and 'Meat, rice and noodles diet' and rs1870377 in Malaysians had significant effects on blood lipids after adjusting for confounders. Conclusions: The association and interaction of dietary patterns and VEGFR2 gene polymorphisms on blood lipids differ between Chinese Malaysian and Japanese subjects by either decreasing or increasing the risk of cardiovascular disease.

並列關鍵字

dietary pattern ； VEGFR2 gene polymorphisms ； blood lipids ； Chinese Malaysian ； Japanese