Tooth transposition is a dental anomaly characterized by the exchange in position of 2 or more teeth within a quadrant of the dental arch. Although the mechanism of tooth transposition is not clear, it seems to be closely related to the development of tooth germs and the process of eruption. The prevalence of maxillary canine transposition is 0.3%. It is very complicated to treat canine transposition caused by root resorption, periodontal destruction, and pulp necrosis. This article describes the orthodontic treatment planning and procedure of a case of bilateral tooth transposition. The etiology, prevalence rate, classification, and diagnosis are also discussed.