本實驗以牙齦培養液及多形核白血球與巨噬細胞之研勻液作材料,以試驗牙菌膜抽出液對其中之隱性膠質酶之激活作用。實驗結果顯示牙菌膜抽出液確具此種激活能力。而此種激活因素可被溫度所破壞,不能破透析,且其本身並無顯著之膠質破壞能力。故牙菌膜與牙周病之膠質破壞作用之間可能有密切的關係。
Activation of latent collagenase in gingival collagenase preparations and homogenates of polymorphonuclear leukocyte and tissue macropbages by sterile extracts of whole human dental microbial plaque was studied. The plaque extracts released substantial latent collagenolytic activity in collagenase preparations. The plaque activation factor was thermolabile, nondialyzable and had essentially no inherent collagenolytic activity.