With the high-scope program teacher group in Zhongshan Girls High school as an example, this present study investigates the effects of art and science teachers' inter-disciplinary team teaching. It conducts a series of interviews, file tracking, and document analysis. The research results are mainly observed in the three aspects. The effects on curriculum show themselves in three functions: ”multiple pedagogies and alternative assessment,” ”group cooperative learning” and ”adaptive teaching”. For students, the effects contribute to four aspects: ”increasing high school girls' interests in science experiments,” ”improving the potency of creative design and observing,” ”enhancing the capacity and attitude of creative thinking” and ”expanding the capacity of teamwork and diversified thinking”. The project also has influences on teacher change, which includes ”accentuation of art teachers' role and value,” ”growth of professional teaching competence and teamwork capacity,” ”awareness and action of sharing and devoting”.