The purpose of this study was to understand adults' smoking perception, behavior and the related factors for developing effective interventions. 1222 qualified samples were collected. Subjects were asked to fill out questionnaires about smoking perception, knowledge, behavior, health locus of control, cues to action, self-efficacy and demographic data. The results of the questionnaires were then analyzed with ANOVA, enter regression and canonical correlation. The following results were found: (1) Subjects' smoking perception is significantly associated with their smoking behavior. (2) ”Demographic characteristics”, ”smoking knowledge”, ”cues to action”, and ”multidimensional health locus of control” are all significantly associated with subjects' smoking perception and behavior. (3) self-efficacy is significantly associated with smokers' tobacco consumption per day. Finally, the researchers recommend these results for clinical nursing and public health nursing.