炎症性疾病受益于鱼油治疗的可能性常见于老年人,可是老年人對魚油的接受性并不确定。这研究旨在评估,對老年人,不同浓度的液態鱼油之适口性、鱼油副作用的频率和程度、和总结鱼油治疗的所有效應。研究分两部分,共計100位患者(≥60岁),完成一项随机单盲的适口性試驗。第一部分,50位受試者,以随机抽样次序,攝取多次液体鱼油樣品(2x10%,40%和100%)。在第二部分,50位受試者分別品尝其中一个鱼油样本,或100%的淡味橄榄油(对照组)。受試者对油样本味道的喜好度,以5点計分的Likert量表來评估。对于油样本之副作用,在品尝后24小时被记录。第一部分的结果表明,9/50受試者报告,随着鱼油的浓度增高,令人不悅的味道亦上昇。有14/50的受試者不喜歡100%鱼油的口味,有7/50的受試者覺得10%鱼油不適口。14/50受試者报告有鱼油的副作用,但这不会影响他们對治疗的依从性。至于第二部分,1/12品尝100%鱼油与0/13品尝10%鱼油或橄榄油的受試者,宣稱有不悅的味道。4/50受試者报告有副作用,而其中2位表示这会阻止他们繼續进行鱼油治疗。结论是,味道本身并不会妨礙鱼油治疗。此外,报告的副作用有可能不是对于鱼油的真正反应,或阻止患者遵从治疗。液体鱼油补充剂老年人可接受,因此針對治疗老年状况应加以调查。
Inflammatory conditions likely to benefit from fish oil therapy are prevalent in older adults however acceptability in this group is uncertain. This study aimed to assess the palatability of a range of liquid fish oil concentrations, the frequency and extent of side effects, and to summarise any effects on adherence to fish oil therapy in older adults. One hundred patients (≥60 years) completed a randomised, single-blind palatability study, conducted in two parts. In part one, 50 subjects, blinded to random sample order, consumed multiple liquid fish oil samples (2x10%, 40% and 100%). In part two, 50 subjects tasted one concentration, or 100% extra light olive oil (control). Pleasantness of taste was scored on a 5-point Likert scale. Side effects were recorded 24-hr post-tasting. Results of part one showed that 9/50 participants reported increasingly unpleasant taste with increasing fish oil concentration. 14/50 reported unpleasant taste for 100% fish oil vs 7/50 for 10%. 14/50 reported side effects which would not affect compliance with therapy. For part two, 1/12 reported unpleasant taste for 100% vs 0/13 for 10% fish oil or control. 4/50 reported side effects and 2/4 indicated these would prevent ongoing fish oil therapy. The authors conclude that taste itself is not a deterrent to fish oil therapy. Furthermore, reported adverse effects may not be a true reaction to fish oil, or dissuade patients from compliance. Liquid fish oil supplements are acceptable to older adults, therefore should be investigated as a therapy for geriatric conditions.
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